5′-CAGUUAGGGUUAG-3′ 2′-O-MeRNA Lyophilized solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A 13-nucleotide 2′-O-MeRNA possessing terminal phosphorothioate linkages. Potently inhibits telomerase activity (IC50 = 2 nM at 23°C and 3 nM at 37°C). Induces apoptosis in cationic lipid treated human epithelial cells. Note: 100 nmol = 469 µg. Purity: ≥90% by HPLC and SDS-PAGE. 5'-2'OMe[C(ps)A(ps)GUUAGGGUU(ps)A(ps)G]-3' Ref.: Herbert, B.-S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14276. Pitts, A.E. and Corey, D.R. 1998. Proc. Natl. Acad. Sci. USA 95, 11549. R: 20/21/22-40; S: 22-36 |