6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman White solid. A benzylisoquinoline alkaloid. Calcium channel antagonist with anti-hypertensive activity. Blocks L-type (IC50 = 0.3-8 µM) and T-type (IC50 = 2.5-20 µM) Ca2+ channels and the Ca2+-activated potassium channel (Kd = 200 nM). Also known to act as an antioxidant and inhibit lipid peroxidation. Purity: ≥98% by TLC. RTECS XE9350000, CAS 518-34-3. Merck Index: 14, 9231
Ref.: Dworetzky, S.I., et al. 1996. J. Neurosci. 16, 4543. Kwan, C.Y. 1995. Clin. Exp. Pharmacol. Physiol. 22, S297. Shi, X., et al. 1995. J. Toxicol. Environ. Health 46, 233. Wang, R.G. and Lemos, J.R. 1994. Life Sci. 56, 295.
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