(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

White solid. Selective inhibitor of TNF-a biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers. Purity: ≥98% by TLC. RTECS TI4375000, CAS 50-35-1.

Merck Index: 14, 9255
Ref.: Gershon, D. 1995. Nat. Med. 1, 1230. Thompson, C. 1995. Lancet 346, 1289. Tramontana, J.M., et al. 1995. Mol. Med. 1, 384. D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
R: 21-25-46-61-62; S: 36/37/39-45-22-26