Colorless solid. PROTECT FROM LIGHT. A cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis in rat thymocytes and in human hepatoma cells. Purity: ≥97% by TLC. CAS 67526-95-8. Ref.: Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
R: 36/37/38-42; S: 36/37/39-26 |
