N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine

White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. PACKAGED UNDER INERT GAS. A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC₅₀ = 2.1 nM for neutral endopeptidase-NEP). Although it is shown to inhibit the activity for Ab peptide degrading enzyme neprilysin in vitro, it has no effect on the secretion of Ab peptide or amyloid b precursor protein (APP). Also reported to inhibit the activity of angiotensin-converting enzyme (ACE) at much higher concentrations (IC₅₀ = 14 µM); however, it does not affect the activity of endothelin-converting enzyme. Purity: ≥95% by TLC. CAS 76721-89-6.

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