rhTpo Lyophilized. Lyophilized from sterile-filtered PBS, 50 µg BSA/µg Tpo. AVOID FREEZE/THAW CYCLES. Recombinant, human thrombopoietin expressed in S. frugiperda insect cells. Glycopeptide hormone that is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitro and in vivo. Ligand for the receptor encoded by the c-mpl proto-oncogene. Promotes the maturation of megakaryocytes and increases platelet size and number. Acts as both a proliferative and a maturation factor of megakaryocytes. Biological activity: ED50 = 1-3 ng/ml as measured in cell proliferation assay using MO7e cells. Purity: ≥97% by SDS-PAGE. Contaminants: Endotoxins: ≤1 EU/µg Tpo. Merck Index: 14, 9386
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