3-bis(4-Methoxyphenyl)methylene-2-indolinone Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable indolinone compound that displays anti-proliferative properties. Potently inhibits growth factor-induced VSMCs (vascular smooth muscle cells) migration and proliferation by blocking voltage-independent Ca2+ influx and downstream signals such as Ca2+/PKC-signaling pathway, leading to AP-1 induction and inhibition of cytoskeletal depolymerization. Reported to prevent neointimal thickening following balloon injury to rat carotid and porcine coronary arteries. Purity: ≥95% by HPLC. Ref.: Sasaki, E., et al. 2001. Pharmacology 63, 17. Sasaki, E., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1043. Sasaki, E., et al. 2000. Jpn. J. Pharmacol. 84, 252. Muranaka, Y., et al. 1998. J. Pharmacol. Exp. Ther. 285, 1280. |
