2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
TR Antagonist, 1-850 Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable hydrazinyl-carboxamide compound that acts as a selective and high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Shown to block T3- (L-triiodothyronine) mediated interaction of TRa with NRC (nuclear receptor coactivator) and prevent the stimulation of gene expression. Exerts no effect on the retinoic acid receptor a (RARa) activity. Purity: ≥95% by HPLC. Ref.: Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354. | 
