N-(3-Indolylmethylene)-isonicotinic Hydrazone Pale yellow solid. PACKAGED UNDER INERT GAS. A non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding. Exhibits significant inhibition of immune responses in animal models of autoimmune disease and allograft transplant rejection, suggesting its potential as a novel immunosuppressant. Does not exhibit any toxic effects in vivo, with normal lymphocyte cellularity and subset composition in the spleen and lymph nodes of mice 24 h after injection. Purity: ≥98% by HPLC. Ref.: Li, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 73. | 
