meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate Purple solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA. Purity: ≥90% by TLC. CAS 36951-72-1. Ref.: Yamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433. Izbicka, E., et al. 1999. Cancer Res. 59, 639. Anantha, N.V., et al. 1998. Biochemistry 37, 2709. Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724. Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261. |
