(RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
Ant-Tirap138-151
Mal Peptide
MyD88-Adapter-Like Peptide
TIRAP Peptide
Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide White lyophilized solid. Supplied as a trifluoroacetate salt. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-kB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells at ~40 µM. Also reported to block IkBa degradation. Purity: ≥97% by HPLC. H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH Ref.: Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392. Fitzgerald, K.A., et al. 2001. Nature 413, 78. Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828. Horng, T., et al. 2001. Nat. Immunol. 2, 835. |
