TPCK White solid. Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by g-interferon and lipopolysaccharides (EC50 = 20 µM). Purity: ≥98% by TLC. RTECS XT5613500, CAS 402-71-1. Ref.: Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488. Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279. Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229. Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
R: 41; S: 26-36 |
