N-(3′,4′-Dimethoxycinnamoyl)anthranilic Acid Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle. Purity: ≥95% by HPLC. RTECS DG8731000, CAS 53902-12-8. Merck Index: 14, 9570
Ref.: Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537. Isaji, M., et al. 1998. Life Sci. 63, PL71. Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
R: 20/21/22; S: 36 |
