Abz-LAQAVRSSSR-Dpa
ADAM-17 Substrate IV, Fluorogenic
TNF-a Convertase Enzyme Substrate IV, Fluorogenic Yellow lyophilized solid. Supplied as a trifluoroacetate salt. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. PACKAGED UNDER INERT GAS. An internally-quenched fluorogenic decapeptide substrate that is useful for continuous monitoring of TACE activity and high-throughput screening of TACE inhibitors (kcat = 21.6 s-1 and substrate concentration at half the Vmax, S0.5 = 342 µM). The substrate is cleaved at Ala-Val amide bond. Acts as a poor substrate for MMP-1, MMP-9, and MMP-13. Displays better solubility in aqueous buffers. Purity: ≥95% by HPLC. Excitation max.: ~320 nm, Emission max.: ~420 nm Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa Ref.: Jin, G., et al. 2002. Anal. Biochem. 302, 269. | 
