2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl
Transforming Growth Factor-b Type I Receptor Kinase Inhibitor III Light yellow solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKa only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases. Purity: ≥97% by HPLC. CAS 356559-13-2. Ref.: Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816. DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744. |
