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  Caspase Inhibitor I
Cat. No. 627610  
All Categories » Calbiochem » Inhibitors » Apoptosis » Caspase

Z-VAD (OMe)-FMK

White solid. PROTECT FROM MOISTURE. A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required. Purity: Single spot by TLC.

Z-Val-Ala-Asp(OMe)-CH2F*

Ref.: Martin, U., et al. 2007. Apoptosis 12, 525. Misaghi, S., et al. 2004. Chem. Biol. 11, 1677. Joo, C., et al. 1999. Ophthalmic Res. 31, 287. McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229. Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312. Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735. An, S. and Know, K.A. 1996. FEBS Lett. 386, 115. Cain, K., et al. 1996. Biochem J. 314, 27. Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266. Pronk, G.J., et al. 1996. Science 271, 808. Slee, E.A., et al. 1996. Biochem. J. 315, 21. Chow, S.C., et al. 1995. FEBS Lett. 364, 134. Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283. Zhu, H., et al. 1995. FEBS Lett. 374, 303.
Sold under license of U.S. Patents 5,210,272 and 5,344,939.

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1 mgYN/A

SolubilityMolecular FormulaMol. Wt.
DMSO C22H30FN3O7 467.5 


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627610: Caspase Inhibitor I - English
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All Categories » Calbiochem » Inhibitors » Apoptosis » Caspase

Selected Citations:
  1. Naohide Watanabe and Eric Lam. (2005) Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. Journal of Biological Chemistry 280, 14691-14699.
  2. Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.