PG490

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-a-induced apoptosis, and inhibits TNF-a-induced activation of NF-kB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-kB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Purity: ≥98% by HPLC. RTECS YK7751000, CAS 38748-32-2.

Ref.: Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology 40, 139.
R: 20/21/22-40; S: 22-36