4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid
TSA Lyophilized solid. A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. Purity: ≥98% by HPLC. RTECS MI5215000, CAS 58880-19-6. Ref.: Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423. Takahashi, I., et al. 1996. J. Antibiot. 49, 453. Taunton, J., et al. 1996. Science 272, 408. Futamura, M., et al. 1995. Oncogene 10, 1119. Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
R: 20/21/22-36/37/38-43; S: 26-36 |
