Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A a-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors g (PPARg). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21Cip1 turnover by inhibiting PKCd signaling in VSMCs. Exerts positive inotropic effect via Ca2+ sensitization in the sarcoplasmic reticulum and inhibits Na+/H+ exchange activity and proliferation of macrovascular endothelial cells. Purity: ≥98% by TLC. RTECS XJ5813130, CAS 97322-87-7. Ref.: Masamune, A., et al. 2002. J. Biol. Chem. 277, 141. Boyault, S., et al. 2001. FEBS Lett. 501, 24. de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120. Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307. Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306. Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909. Koga, H., et al. 2001. Hepatology 33, 1087. Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731. Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440. Takashima, T., et al. 2001. Int. J. Oncol. 19, 465. Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950. Tanaka, T., et al. 2001. Cancer Res. 61, 2424. Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650. |
