TNF-a Antagonist
Tumor Necrosis Factor-a Antagonist
WP9QY Lyophilized. Supplied as a trifluoroacetate salt. HYGROSCOPIC. An exocyclic peptidomimetic that acts as a TNF-a antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-a-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-b/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr. Purity: ≥95% by HPLC. H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8) Ref.: Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
Sold under license of U.S. Patent 6,265,535. | 
