(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
a-Cyano-(3,4-dihydroxy)-N-benzylcinnamide
Tyrphostin B42 Yellow solid. PROTECT FROM LIGHT. Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Inhibition of JAK2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Purity: ≥98% by HPLC. CAS 133550-30-8. Ref.: Jaleel, M., et al. 2004. Biochemistry 43, 8247. Eriksen, K.W., et al. 2001. Leukemia 15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913. |
