5H4
a-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide
NSC D722757 Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo. Purity: ≥98% by HPLC. Ref.: Gu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269. |
