a-Cyano-(3-methoxy,4-hydroxy,5-iodo)cinnamoyl-(3′,4′-dihydroxyphenyl)ketone
Tyrphostin I-OMe-AG 538 Dark yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable analog of AG 538 (Cat. No. 658403) that acts as a competitive inhibitor of IGF-1 receptor kinase in intact cells in a dose-dependent manner. Exhibits enhanced cell-permeability and more resistance towards oxidation. Reported to inhibit IGF-1R kinase autophosphorylation (IC50 = 3.4 µM) as well as the phosphorylation of the PTK substrate poly(Glu,Tyr) (IC50 = 2 µM). Also inhibits the activation of the downstream targets PKB and ERK2 with the same potency as AG 538. Purity: ≥95% by HPLC. Ref.: Blum, G., et al. 2000. Biochemistry 39, 15705. |
