6,7-Dimethyl-2-phenylquinoxaline Yellow solid. PROTECT FROM LIGHT. Selectively inhibits platelet-derived growth factor (PDGF) receptor kinase (IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 µM) in Swiss/3T3 cells. Has no effect on EGF receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis. A potent blocker of smooth muscle cell proliferation. Purity: ≥95% by HPLC. CAS 71897-07-9. Ref.: Banai, S., et al. 1998. Circulation 97, 1960. Levitzki, A., and Gazit, A. 1995. Science 267, 1782. Kovalenko, M., et al. 1994. Cancer Res. 54, 6106. |
