3b-(2-Diethylaminoethoxy)androst-5-en-17-one, HCl Lyophilized. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol, presumably via its inhibitory effect on 2,3-oxidosqualene-lanosterol cyclase activity. Also reported to inhibit the activity of D8-sterol isomerase. Purity: ≥95% by TLC. CAS 3039-71-2. Ref.: Hall, A.M., et al. 2003. Pigment Cell Res. 16, 149. Kobayashi, T., et al. 1998. Nature 392, 193. Liscum, L. and Faust, J.R., 1989. J. Biol. Chem. 264, 11796. Sexton, R.C., et al. 1983. Biochemistry 22, 5687. Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res. 150, 343. |
