LDN-57444
Ubiquitin C-Terminal Esterase L1 Inhibitor
Ubiquitin C-Terminal Hydrolase L1 Inhibitor
Ubiquitin Thiolesterase L1 Inhibitor Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type. Purity: ≥95% by HPLC. Ref.: Liu, Y., et al. 2003. Chem. Biol. 10, 837. |
