3,5-bis((4-Methylphenyl)methylene)-1,1-dioxide, piperidin-4-one
NSC-632839 Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable cross-conjugated a,b-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 15.65 and 16.23 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for F6-activated apoptosis, while Bcl-2 appears to protect cells against the effect of F6. Purity: ≥97% by HPLC. Ref.: Aleo, E., et al. 2006. Cancer Res. 66, 9235. |
