White crystalline solid. A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K⁺ conductivity in cell membranes at concentrations as low as 10^-8 M. Often used in membrane electrode systems for determining K⁺ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation. Purity: ≥93% by HPLC. RTECS YV9468000, CAS 2001-95-8.

Merck Index: 14, 9910
Ref.: Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310. Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12. Orlov, V.N., et al. 1994. FEBS Lett. 345, 104. Acra, S., et al. 1993. Am. J. Physiol. 264, G45. Cornet, M., et al. 1993. J. Membr. Biol. 131, 55. Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362. Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734. Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280. Pape, P.C., et al. 1992. J. Physiol. 449, 219. Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105. Lerner, A., et al. 1982. FEBS Lett. 146, 9.
R: 26/27/28; S: 22-36/37/39-45