2-Propylpentanoic Acid, Na

White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3a and -3b, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models. Purity: ≥98% by titration. RTECS YV7876000, CAS 1069-66-5.

Merck Index: 14, 9913
Ref.: Gottlicher, M., et al. 2001. EMBO J. 20, 6969. Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347. Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734. Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466. Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674. Chen, G., et al. 1999. J. Neurochem. 72, 1327.
R: 20/21/22-36/37/38-61; S: 3/7/9-22-36/37/39-45