(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one
VEGF Receptor 2 Kinase Inhibitor I Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. Does not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 > 100 µM). Purity: ≥95% by HPLC. CAS 15966-93-5. Ref.: Sun, L., et al. 1998. J. Med. Chem. 41, 2588. |
