GS4012
4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. Purity: ≥97% by HPLC. Ref.: Peterson, R.T., et al. 2004. Nat. Biotechnol. 22, 595. Depre, C., et al. 2003. Circulation 108, 2723. |
