(RTELNVGIDFNWEYPAS)2K-NH2 White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/Flk-1) comprising residues 247 - 261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 and inhibits the proliferation and migration of cultured microvascular endothelial cells. Binds to VEGF and blocks its interaction with VEGFR-2 (IC50 = 500 nM on extracellular VEGFR-2 fragments; IC50 = 30 µM on HUVEC). Purity: ≥90% by HPLC. (H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)2-Lys-NH2 Ref.: Piossek, C., et al. 1999. J. Biol. Chem. 274, 5612. | 
