White solid. A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro. Purity: ≥99% by titration (with perchloric acid). RTECS YV8320000, CAS 152-11-4. Merck Index: 14, 9950
Ref.: Lonsberry, B.B., et al. 1994. Pharmacology 49, 23. Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027. Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
R: 23/24/25; S: 22-36/37/39-45 |
