White to off-white solid. A Na+ channel opener. Increases intracellular Ca2+ levels without affecting Na+ - Ca2+ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. Induces cell death in bovine chromaffin cells. Purity: ≥98% by TLC. RTECS YX5600000, CAS 71-62-5. Merck Index: 14, 9954 Ref.: Maroto, R., et al. 1994. Eur. J. Pharmacol. 270, 331. Plattner, H., et al. 1994. J. Membr. Biol. 142, 229. Rando, T.A., et al. 1989. J. Gen. Physiol. 93, 43. Rando, T.A., et al. 1986. Mol. Pharmacol. 29, 467. R: 26/27/28; S: 26-36/37/39-45 |