White crystalline solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Antitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases frequency of micronucleated erythrocytes. RTECS YY8400000, CAS 143-67-9.

Merck Index: 14, 9982
Ref.: Tanaka, E., et al. 1995. J. Cell. Biol. 128, 139. Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374. Smith, C.D., et al. 1994. Cancer Lett. 79, 213. Smith, C.D., et al. 1994. Cancer Res. 54, 3779. Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198. Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87. Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401. Prasad, V., et al. 1992. J. Protein Chem. 11, 509.
R: 22-37/38-61-41; S: 22-26-36/37/39-45