White solid. Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules. Purity: ≥99% by TLC. RTECS OH6340000, CAS 2068-78-2. Merck Index: 14, 9986 Ref.: Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347. Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688. Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187. R: 36/37/38-60-61; S: 22-26-36/37/39-45 |