Calcitriol
1,25-(OH)2-D3 Solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Purity: ≥99% by HPLC. RTECS FZ4645000, CAS 32222-06-3. Merck Index: 14, 1644
Ref.: Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Mathieu, C., et al. 1994. Diabetologica 37, 552. Thomasset, M. 1994. Pathol. Biol. 42, 163. Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804. Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020. Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189. Wakasugi, M., et al. 1991. Prostaglandins 42, 127. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916. Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710. DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
R: 26/27/28-63; S: 36/37/39-45 |
