4-(3′-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, HCl Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site. Purity: ≥95% by HPLC. Ref.: Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133. Chen, C.L., et al. 1999. Pharm. Res. 16, 117. |
