4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A pyrrolocarbazole compound that acts as a potent and ATP-competitive inhibitor of checkpoint kinases Wee1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). Inhibits PKC, Cdk4, or other CDKs only at much higher concentrations (IC50 = 3.4 µM, 3.75 µM, and >5 µM, respectively) and exhibits little effect against FGFR, PDGFR, or c-Src (IC50 >50 µM). Purity: ≥95% by HPLC. Ref.: Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896. Squire, C.J., et al. 2005. Structure 13, 541. |
