cyclo(LKDFDPDFLFDPLQ)2 White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~ 2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex by inhibiting the interaction between N-WASP and Arp2/3. Purity: ≥95% by HPLC. cyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)2 Ref.: Peterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624. Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175. |
