[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid

White crystalline solid. One of the most potent peroxisome proliferator-activated receptor a (PPARa) ligands. Inhibits TNF-a induced expression of VCAM-1 in endothelial cells. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent. Purity: ≥98% by HPLC. RTECS AG2915000, CAS 50892-23-4.

Ref.: Marx, N., et al. 1999. Circulation 99, 3125. Murakami, K., et al. 1999. Biochem. Biophys. Res. Commun. 260, 609. Tugwood, J.D., et al. 1996. Ann. N.Y. Acad. Sci. 804, 252. Keller, H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2160. Keller, H., and Wahli, W. 1993. Trends Endocrinol. Metab. 4, 291. Dreyer, C., et al. 1992. Cell 68, 879. Issemann, I., and Green, S. 1990. Nature 347, 645.
R: 22-36/37/38-45; S: 26-36/37/39-45-53