XeC White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the endoplasmic reticulum stores in a reversible manner. Purity: ≥90% by TLC. Ref.: Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959. Gafni, J., et al. 1997. Neuron 19, 723. Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111. Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876. Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505. Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
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