7-Aza-2-phenylbenzisothizol-3-one Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An isothiazolone derivative that inhibits the activation of pro-MMPs but does not affect the activity of active MMPs. Causes dose-dependent inhibition of IL-1-b-induced breakdown of proteoglycan in a cartilage organ culture assay (IC50 = 4.4 µM). Purity: ≥95% by HPLC. Ref.: Arner, E.C., et al. 1996. Biochem. J. 318, 417. Wright, S.W., et al. 1994. J. Med. Chem. 37, 3071. | 
