| | Anti-Bak (Ab-1) Mouse mAb (TC-100) |
|  | Cat. No. AM03 |
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Anti-Bcl-2 Antagonist Killer | Host: Mouse | | Isotype: IgG2a | | Immunogen: recombinant human Bak from which the C-terminal and transmembrane domains have been deleted | | Epitope: Within the N-terminal region | | Form: Liquid | | Formulation: In 0.05 M sodium phosphate buffer, 0.2% gelatin. | | Preservative: ≤0.1% sodium azide | | Positive Control: HL-60 cells | | Comments: Recognizes the ~30 kDa (apparent MW) Bak protein in HL-60 cells. | | Ref.: Chittenden, T., et al. 1995. Nature 374, 733. Farrow, S.N., et al. 1995. Nature 374, 731. Kiefer, M.C., et al. 1995. Nature 736. Reed, J.C. 1994. J. Cell Biol. 124, 1. Korsmeyer, S.J., et al. 1993. N. Semin. Cancer Biol. 4, 327. |
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EMD Chemicals Inc. list price is displayed (pricing with local distributors may vary). NOTE: In Stock status is based on item availability worldwide.
| TC-100 | human
not mouse, not rat | IB
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EMD Chemicals Inc. list price is displayed (pricing with local distributors may vary). NOTE: In Stock status is based on item availability worldwide.
| Anti-Bak (Ab-1) Mouse mAb (TC-100) | AM03T | 10 µg | Y | N/A |
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Detection of human Bak by immunoblotting. Sample: Whole cell lysates from untreated HL-60 cells. Primary antibody: Anti-Bak (Ab-1) Mouse mAb (TC-100) (Cat. No. AM03) (2 µg/ml). Detection: chemiluminescence.
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| - Lena Thyrell, et al. (2004) Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathways. Journal of Biological Chemistry 279, 24152-24162.
- Aleksandra Mandic, et al. (2001) Cisplatin induces the proapoptotic conformation of Bak in a ΔMEKK1-dependent manner. Molecular and Cellular Biology 21, 3684-3691.
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