Host: Rabbit

Isotype: IgG

Immunogen: a synthetic peptide corresponding to C-terminal amino acids adjacent to Asp230 of human lamin A

Form: Liquid

Formulation: In 150 mM NaCl, 10 mM sodium HEPES, 100 µg/ml BSA, 50% glycerol, pH 7.5.

Preservative: None

Positive Control: HeLa cells treated with staurosoporine

Negative Control: Normal rabbit IgG (Cat. No. NI01)

Comments: Recognizes the ~45-50 kDa large subunit of lamins A and C in staurosporine-treated HeLa cells. Does not recognize full length lamin A.

Ref.: MacLachlan, T.K. and El-Deiry, W.S. 2002. Proc. Natl. Acad. Sci. USA 99, 9492. Orth, K., et al. 1996. J. Biol. Chem. 271, 16443.