p53 is a tumor suppressor protein that is activated following DNA damage, ultraviolet light, and treatment with chemotherapeutic agents. It is also one of the most frequently mutated genes in cancer. Under normal conditions p53 levels are kept low because of its rapid degradation in the ubiquitin-proteasome pathway. p53 can also act as a transcription factor to help regulate cell cycle progression and apoptosis. This flyer details the many antibodies available to study p53 and the many proteins it interacts with. p53 is the current focus of active research to understand it regulation and activation in health and disease. | |
