| Format: 96-well plate | | Form: 96 Tests | | Species Reactivity: human, mouse, rat | | Sensitivity: <4 ng/ml | | Assay Range: 0.78-50 ng/ml | | Assay Time: 4 h | | Sample Type: Cells | | Kit Contents: Coated 96-Well Plate, c-Met Standard, Diluents, Detector Antibody, Secondary Antibody, Wash Buffer, TMB Substrate, Stop Solution, Plate Sealers, and a user protocol. | | Comments: Detects and quantifies the levels of c-Met protein independent of its phosphorylation state. The ligand for c-Met, HGF/SF, is a member of the plasminogen-related growth factor family, which is synthesized as an inactive pro-form. HGF/SF stimulation of c-Met expressing cells enhances proliferation, migration, morphogenesis, and protease synthesis, characteristics that are associated with invasive cell phenotype. This kit is designed for use with human samples. | | Ref.: Kang, J.Y, et al. 2003. Cancer Res. 63, 1101. Zhang, X., et al. 2003. Am. J. Renal Physiol. 284, F82. Maulik, G., et al. 2002. Cytokine Growth Factor Rev. 13, 41. Crostella, L., et al. 2001. Oncogene 20, 3735. Fan, S., et al. 2001. Mol. Cell. Biol. 21, 4968. Longati, P., et al. 2001. Curr. Drug Targets 2, 41. Matsumoto, K. and T. Nakamura 2001. Kidney Int. 59, 2023. Parr, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 1330. Follenzi, A., et al. 2000. Oncogene 19, 3041. Furge, K.A., et al. 2000. Oncogene 19, 5582. Wei, L., et al. 1995. J. Biol. Chem. 270, 8122. Guiton, M., et al. 1994 J. Biol. Chem. 269, 30370. Park, M., et al. 1987. Proc. Nat'l. Acad. Sci. 84, 6379. | |