Ant-Murine Double Minute Chromosome-2

Host: Rabbit

Isotype: IgG

Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Ser166 phosphorylation site of human MDM2

Form: Liquid

Formulation: In 150 mM NaCl, 10 mM HEPES, 100 µg/ml BSA, 50% glycerol, pH 7.5.

Preservative: None

Positive Control: MCF7 cells treated with IGF-1

Comments: Recognizes the ~90 kDa (apparent MW) MDM2 protein phosphorylated at Ser166 in IGF-1-treated MCF-7 cells.

Ref.: Mayo, L.D., and Donner, D.B. 2001. Proc. Natl. Acad. Sci. USA 98, 11598. Zhou, B.P., et al. 2001. Nat. Cell. Biol 3, 973. Grossman, S.R., et al. 1998. Mol. Cell 2, 405. Haupt, Y., et al. 1997. Nature 387, 296.