Host: Mouse

Isotype: IgG1

Immunogen: a human p53 fusion protein

Epitope: within amino acids 46-55 of human p53

Form: Liquid

Formulation: In 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.

Preservative: ≤0.1% sodium azide

Positive Control: A431 cells or breast carcinoma tissue

Negative Control: SK-OV-3 cells or normal skin

Comments: Recognizes the ~53 kDa wild-type and mutant p53 protein in A-431 cells and breast carcinoma tissue.

Ref.: El-Deiry, W.S., et al. 1994. Cancer Res. 54, 1169. Greenblatt, M.S., et al. 1994. Cancer Res. 54, 4855. Barak, Y., et al. 1993. EMBO J. 12, 461. Kastan, M.B., et al. 1992. Cell 71, 587. Kuerbitz, S.J. 1992. Proc. Natl. Acad. Sci. USA 89, 7491. Lane, D.P. 1992. Nature 358, 15. Kastan, M.B., et al. 1991. Cancer Res. 51, 6304.