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| | Anti-MDM2 (Ab-3) Mouse mAb (4B11) |
|  | Cat. No. OP143 |
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Anti-Murine Double Minute Chromosome-2
Anti-p53 Binding Protein
Anti-Ubiquitin Protein Ligase | Host: Mouse | | Isotype: IgG2a | | Immunogen: full-length, recombinant human MDM2 | | Epitope: within amino acids 383-491 | | Form: Liquid | | Formulation: In 50 mM sodium phosphate buffer, 50% glycerol. | | Preservative: None | | Positive Control: A549 cells | | Comments: Recognizes the ~90 kDa (apparent MW) MDM2 protein in A549 cells. May also recognize the ~60 kDa and ~90 kDa isoforms of MDM2. | | Ref.: Marchetti, A., et al. 1995. J. Pathol. 175, 31. Barak, Y., et al. 1993. EMBO. J. 12, 461. Ladanyi, M., et al. 1993. Cancer Res. 53, 16. Leach, F. S., et al. 1993. Cancer Res. 53, 2231. Oliner, J. D., et al. 1993. Nature 362, 857. Momand, J., et al. 1992. Cell 69, 1237. Oliner, J. D., et al. 1992. Nature 358, 80. Fakharzadeh, S. S., et al. 1991. EMBO. J. 10, 1565. |
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| 4B11 | human, mouse | IB, IF, IP, PS
See Key |
Detection of human MDM2 by staining paraffin sections. Sample: Breast carcinoma. Primary antibody: Anti-MDM2 (Ab-3) Mouse mAb (4B11) (Cat. No. OP143) (2.5 mg/ml). Detection: DAB
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| - Fang Zhang, et al. (2006) Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. Journal of Biological Chemistry 281, 30036-30045.
- Krishna P. Bhat, et al. (2004) Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. The EMBO Journal 23, 2402-2412.
- Aiwen Jin, et al. (2004) Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Molecular and Cellular Biology 24, 7669-7680.
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